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santacruz GSK-3 Inhibitor X

  • 更新時間：  2023-07-25
  • 產(chǎn)品型號：  SC-221689
  • 簡單描述
  • santacruz GSK-3 Inhibitor X
    分子量: 398.2
    分子式: C18H12BrN3O3
    可溶性: Soluble in DMSO
詳細(xì)介紹

santacruz GSK-3 Inhibitor X
santacruz GSK-3 Inhibitor X詳細(xì)產(chǎn)品信息：

GSK-3 Inhibitor X (CAS 740841-15-0)

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Synonym:BIO-Acetoxime; 6-Bromoindirubin-3′-acetoxime, BIA
Application:A selective GSK-3α/β inhibitor
CAS Number:740841-15-0
Purity:≥95%
Molecular Weight:398.21
Molecular Formula:C18H12BrN3O3
Refer to Certificate of Analysis for lot specific data (including water content).
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GSK-3 Inhibitor Xsc-2216891 mg$115 Add 

Description

GSK-3 Inhibitor X is an acetoxime analog of BIO which acts as a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). GSK-3 Inhibitor X induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Technical Information

Physical State:Solid
Solubility:Soluble in DMSO (10 mg/ml).
Storage:Store at 4° C
Melting Point:236.83 °C (Predicted)
Boiling Point:551.87 °C (Predicted)
Density:1.69 g/cm3 (Predicted)
Refractive Index:n20D 1.74 (Predicted)
IC50:GSK-3α/β: IC50 = 10 nM; Cdk5/p25: IC50 = 2.4 µM; Cdk2/A: IC50 = 4.3 µM; Cdk1/B: IC50 = 63 µM; Cdk4/D1: IC50 = ≥10 µM; aryl hydrocarbon receptor: EC5050 = ≥0.1 µM (yeast); aryl hydrocarbon receptor: EC5050 = 0.16 µM (mammalian)
pK Values:pKa: 9.23 (Predicted)

Safety and Reference Information

PubChem CID:6538818
MDL Number:MFCD09037533
SMILES:CC(=O)ONC1=C2C=CC=CC2=NC1=C3C4=C(C=C(C=C4)Br)NC3=O

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.


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